Lists & References

DEA Diversion Schedule I Drugs list

First Generation Antihistamines – sedative effects

  

First Generation AntiDepressants – sedative side effects

List of TCAs (Tricyclic Antidepressants – courtesy wikipedia)

Those that preferentially inhibit the reuptake of serotonin (by at least 10 fold over norepinephrine) include:

• Clomipramine (Anafranil) (~200× selective for serotonin over norepinephrine reuptake)
• Imipramine (Tofranil, Janimine, Praminil)

Those that preferentially inhibit the reuptake of norepinephrine (by at least 10 fold over serotonin) include:

• Desipramine (Norpramin, Pertofrane)
• Dibenzepin‡ (Noveril, Victoril)
• Lofepramine§ (Lomont, Gamanil)
• Nortriptyline (Pamelor, Aventyl, Norpress)
• Protriptyline (Vivactil)

Whereas fairly balanced serotonin-norepinephrine reuptake inhibitors include:

• Amitriptyline (Tryptomer, Elavil, Endep)
• Amitriptylinoxide (Amioxid, Ambivalon, Equilibrin)
• Amoxapine (Asendin) – can be classed with the tetracyclic antidepressants (TeCAs) but more frequently classed with the secondary amine TCAs.
• Butriptyline† (Evadyne)
• Demexiptiline† (Deparon, Tinoran)
• Dimetacrine† (Istonil, Istonyl, Miroistonil)
• Dosulepin§ (Prothiaden)
• Doxepin (Adapin, Sinequan)
• Imipraminoxide† (Imiprex, Elepsin)
• Melitracen§ (Deanxit, Dixeran, Melixeran, Trausabun)
• Metapramine† (Timaxel)
• Nitroxazepine‡ (Sintamil)
• Noxiptiline‡ (Agedal, Elronon, Nogedal)
• Pipofezine‡ (Azafen/Azaphen)
• Propizepine† (Depressin, Vagran)
• Quinupramine† (Kevopril, Kinupril, Adeprim, Quinuprine)

and the following are TCAs that act via other mechanisms beside serotonin-norepinephrine reuptake inhibition:

• Amineptine‡ (Survector, Maneon, Directim) – norepinephrine-dopamine reuptake inhibitor
• Iprindole† (Prondol, Galatur, Tetran) – 5-HT₂ receptor antagonist
• Opipramol‡ (Insidon, Pramolan, Ensidon, Oprimol) – σ receptor agonist
• Tianeptine‡ (Stablon, Coaxil, Tatinol) – indirect alteration of AMPA and NMDA glutamate receptor activity
• Trimipramine (Surmontil) – 5-HT₂ receptor antagonist and moderate-potency serotonin reuptake inhibitor.

Tetracyclic antidepressants (TeCAs)

• Amoxapine (Asendin)
• Maprotiline (Ludiomil)
• Mianserin (Bolvidon, Norval, Tolvon)
• Mirtazapine (Remeron)
• Setiptiline (Tecipul)

Mianserin, mirtazapine, and setiptiline are also sometimes described as noradrenergic and specific serotonergic antidepressants (NaSSAs).

Monoamine oxidase inhibitors (MAOIs)

• Isocarboxazid (Marplan)
• Phenelzine (Nardil)
• Tranylcypromine (Parnate)
• Selegiline (Eldepryl, Zelapar, Emsam)
• Metralindole (Inkazan)
• Moclobemide (Aurorix, Manerix)
• Pirlindole (Pirazidol)
• Toloxatone (Humoryl)

AntiPsychotics

Here is an excellent listing of antipsychotic and other psychiatric medications from the NIMH – National Institute of Mental Health

Excerpted here:

Older or first-generation antipsychotic medications are also called conventional “typical” antipsychotics or “neuroleptics”. Some of the common typical antipsychotics include:

• Chlorpromazine
• Haloperidol
• Perphenazine
• Fluphenazine

Newer or second-generation medications are also called “atypical” antipsychotics. Some of the common atypical antipsychotics include:

• Risperidone
• Olanzapine
• Quetiapine
• Ziprasidone
• Aripiprazole
• Paliperidone
• Lurasidone

Benzodiazepines

Recommended to wait 7 half-lives after discontinuation before resuming commercial driving: (see MEP report download)

  

  

Medications for MS: (from the National Multiple Sclerosis Society)

• Injectable medications
  • Avonex (interferon beta-1a)
  • Betaseron (interferon beta-1b)
  • Copaxone (glatiramer acetate)
  • Extavia (interferon beta-1b)
  • Glatopa (glatiramer acetate — generic equivalent of Copaxone 20mg dose)
  • Plegridy (peginterferon beta-1a)
  • Rebif (interferon beta-1a)
• Oral medications
  • Aubagio (teriflunomide)
  • Gilenya (fingolimod)
  • Tecfidera (dimethyl fumarate)
• Infused medications
  • Lemtrada (alemtuzumab)
  • Novantrone (mitoxantrone)
  • Tysabri (natalizumab)

Parkinson’s Disease

  

AntiMalaria Drugs

Hydroxychloroquine, mefloquine, atovaquone and proguanil, chloroquine phosphate oral, and quinine may cause dizziness, fatigue, myopathy and weakness, decreased visual accommodation, disturbance in color perception, and visual field defects. Some of these medications contain a warning related to fine motor coordination and decreased alertness and the ability to operate a motor vehicle safely, with a 34% increased crash risk. ref:

Potentially Driver Impairing Medications (requires Medscape login)

Chantix

Causes:

• Accidents and injuries. A total of 173 serious events from falls and traffic accidents, with multiple fracture injuries, from loss of consciousness, mental confusion, dizziness and muscle spasms.
• Vision disturbance. At least 148 reports of vision disturbances, including blurred vision and some forms of blindness.
• Heart rhythm disturbances. The FDA received 224 reports of potential cardiac rhythm disturbances and loss of consciousness.
• Seizures and abnormal muscle spasms or movements.  Convulsions (seizures), tremors, muscle spasms, twitching, tics, drooling, and motor hyperactivity.
• Moderate and severe skin reactions. Hives or swelling of the tongue, face, eyes, lips or other areas.
• Diabetes. Loss of glycemic control.

ref: https://naohp.com/wp-content/uploads/Chantix-letter-from-FMCSA.pdf

Herbal Products

Use of Herbal Products and Potential Interactions in Patients With Cardiovascular Diseases

Additional Resources/References

ACOEM Practice Guidelines on Opioids