Lesson 1, Topic 1
In Progress

Lists & References

DEA Diversion Schedule I Drugs list

First Generation Antihistamines – sedative effects

 H1_antagonist_-_Wikipedia 

First Generation AntiDepressants – sedative side effects

List of TCAs (Tricyclic Antidepressants – courtesy wikipedia)

Those that preferentially inhibit the reuptake of serotonin (by at least 10 fold over norepinephrine) include:

  • Clomipramine (Anafranil) (~200× selective for serotonin over norepinephrine reuptake)
  • Imipramine (Tofranil, Janimine, Praminil)

Those that preferentially inhibit the reuptake of norepinephrine (by at least 10 fold over serotonin) include:

Whereas fairly balanced serotonin-norepinephrine reuptake inhibitors include:

and the following are TCAs that act via other mechanisms beside serotonin-norepinephrine reuptake inhibition:

Tetracyclic antidepressants (TeCAs)

Mianserin, mirtazapine, and setiptiline are also sometimes described as noradrenergic and specific serotonergic antidepressants (NaSSAs).

Monoamine oxidase inhibitors (MAOIs)

AntiPsychotics

Here is an excellent listing of antipsychotic and other psychiatric medications from the NIMH – National Institute of Mental Health

Excerpted here:

Older or first-generation antipsychotic medications are also called conventional “typical” antipsychotics or “neuroleptics”. Some of the common typical antipsychotics include:

Newer or second-generation medications are also called “atypical” antipsychotics. Some of the common atypical antipsychotics include:

Benzodiazepines

Recommended to wait 7 half-lives after discontinuation before resuming commercial driving: (see MEP report download)

 Medical-Expert-Panel-Psychiatric-Psychiatric-MEP-Panel-Opin__page_8_of_23_ 

 Medical-Expert-Panel-Psychiatric-Psychiatric-MEP-Panel-Opin__page_9_of_23_ 

Medications for MS: (from the National Multiple Sclerosis Society)

Parkinson’s Disease

 PD_Final_pdf 

AntiMalaria Drugs

Hydroxychloroquine, mefloquine, atovaquone and proguanil, chloroquine phosphate oral, and quinine may cause dizziness, fatigue, myopathy and weakness, decreased visual accommodation, disturbance in color perception, and visual field defects. Some of these medications contain a warning related to fine motor coordination and decreased alertness and the ability to operate a motor vehicle safely, with a 34% increased crash risk. ref:

Potentially Driver Impairing Medications (requires Medscape login)

Chantix

Causes:

  • Accidents and injuries. A total of 173 serious events from falls and traffic accidents, with multiple fracture injuries, from loss of consciousness, mental confusion, dizziness and muscle spasms.
  • Vision disturbance. At least 148 reports of vision disturbances, including blurred vision and some forms of blindness.
  • Heart rhythm disturbances. The FDA received 224 reports of potential cardiac rhythm disturbances and loss of consciousness.
  • Seizures and abnormal muscle spasms or movements.  Convulsions (seizures), tremors, muscle spasms, twitching, tics, drooling, and motor hyperactivity.
  • Moderate and severe skin reactions. Hives or swelling of the tongue, face, eyes, lips or other areas.
  • Diabetes. Loss of glycemic control.

ref: https://naohp.com/wp-content/uploads/Chantix-letter-from-FMCSA.pdf

Herbal Products

Use of Herbal Products and Potential Interactions in Patients With Cardiovascular Diseases

Additional Resources/References

ACOEM Practice Guidelines on Opioids

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